The isolation of
therapeutic molecules from bacterial cell growth is
hampered by the need to remove endotoxins and pyrogens.
Many different commercial techniques are in place in an
attempt to remove these endotoxins, which are
lipopolysaccharide components of bacterial cell walls.
Pyrogen (formerly named Alumina P) using either
column chromatography or batch processing methods, has
proven to be a superior tool for the isolation and
removal of pyrogens. The surface of activated alumina
may be chemically modified to help enhance pyrogen
removal. Furthermore, the amphoteric property of
activated alumina offers unique purification advantages
allowing Alumina P to be used either as a single step or
as part of a two step purification process for the
isolation and removal of endotoxins.
DAI offers a specially
designed superior Alumina which may prove to be just
what you need for the removal of endotoxins and pyrogens
from your bacterial cell culture system.
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